Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 22, 2026Journal of Functional BiomaterialsOpen Access

An Injectable Biopolymer Hydrogel Complex (PN/HA/B3) for Facial Skin Redensification and General Rejuvenation: Clinical Report on Device Safety and Efficacy

View Full Paper
Ask AI
Bookmark
Share

Authors

APAlexandre PorcelloKLKelly LourençoCMCíntia Marques

Discussion

Loading...

Member takes

Overview

Clinical report evaluates safety and efficacy of injectable hydrogel in improving facial skin quality.

Key Points

  • The study aims to assess the safety and effectiveness of an injectable device containing HA, PN, and niacinamide for skin rejuvenation.
  • Prospective, open-label clinical investigation with 42 female subjects (mean age 45 years).
  • Evaluated skin quality using GAIS, Antera 3D®, Cutometer®, Corneometer®, and Dermascan® at baseline, week 2, and week 6.
  • Monitored injection site reactions and overall satisfaction post-injection.
  • GAIS values indicated significant facial improvement (p < 0.001) at week 6.
  • Objective measures showed significant enhancement in skin texture, elasticity, hydration, density, and thickness (p < 0.001).
  • High satisfaction reported by both investigators and subjects regarding the injection experience and outcomes.

Cite This Study

Porcello et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff33bd674f7c03778bd0fhttps://doi.org/10.3390/jfb17050254
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Real-World Evaluation of an Injectable Treatment Containing Polynucleotides Purified with High Purification Technology (PN HPT) and Hyaluronic Acid for Skin Quality Improvement in Facial and Body Areas2026 · 2 citations
  2. 2Hybrid Calcium Hydroxylapatite–Polynucleotide Skin Booster A Retrospective Cohort Study2026
  3. 3Intradermal Treatment with a Hyaluronic Acid Complex Supplemented with Amino Acids and Antioxidant Vitamins Improves Cutaneous Hydration and Viscoelasticity in Healthy Subjects2024 · 26 citations
  4. 4Efficacy and Safety of Non-cross-Linked Hyaluronic Acid Injections for Facial Skin Biorevitalization: A Single-Center, Open-Label, Single-Arm, Uncontrolled, Post-marketing Study2025 · 6 citations
  5. 5Safety and Efficacy of an Injectable Solution Enriched With Sodium Hyaluronate, Amino Acids, and Peptides in Relation to Superficial Facial Connective Tissues (Dermis and Retinacular Cutis)2024 · 2 citations