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August 16, 2025CureusOpen Access

Efficacy and Safety of Non-cross-Linked Hyaluronic Acid Injections for Facial Skin Biorevitalization: A Single-Center, Open-Label, Single-Arm, Uncontrolled, Post-marketing Study

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Authors

SCStefano ChahineUniversity of SannioBMBarbara MarozziPuglia SaluteAVAlessandro ValleUniversity of Brescia

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Overview

Open-label trial shows significant skin hydration improvement in adults with facial photoaging, indicating benefits of hyaluronic acid injections.

Key Points

  • The mean skin capacitance increased from 23.1 to 33.2 arbitrary units, indicating improved skin hydration after treatment.
  • Participants reported high satisfaction levels with the treatment, with no adverse events encountered during the trial.
  • Assessment of skin texture and tone also showed moderate improvements following the biorevitalization injections.
  • Further randomized controlled trials are needed to confirm the efficacy and long-term effects of the treatment.

Cite This Study

Chahine et al. (2025) studied this question.

synapsesocial.com/papers/68a366a80a429f797332c918https://doi.org/10.7759/cureus.90005
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluating Efficacy and Tolerability of a New Intradermal Biorejuvenation with Free Hyaluronic Acid and Glycerol in Photoaging: A Retrospective Pilot Study2025
  2. 2Intradermal Treatment with a Hyaluronic Acid Complex Supplemented with Amino Acids and Antioxidant Vitamins Improves Cutaneous Hydration and Viscoelasticity in Healthy Subjects2024 · 26 citations
  3. 3Clinical evaluation of the effect of non-crosslinked hyaluronic acid injections on skin parameters with signs of aging. Case study2025
  4. 4HYALURONIC ACID BEYOND SKIN REJUVENATION: THE INTERSECTION BETWEEN BEAUTY AND SAFETY IN COMPLIANCE WITH THE NEW EU MEDICAL DEVICES REGULATION2024
  5. 5Efficacy and Safety of a New Crosslinked Hyaluronic Acid Dermal Filler for Facial Volume Restoration: A Prospective Clinical Trial2026