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December 8, 2025CosmeticsOpen Access

Evaluating Efficacy and Tolerability of a New Intradermal Biorejuvenation with Free Hyaluronic Acid and Glycerol in Photoaging: A Retrospective Pilot Study

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Authors

FTFederica TrovatoAGAntonio Di GuardoGPGiovanni Pellacani

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Overview

Retrospective pilot study shows improved skin quality markers in photoaging with hyaluronic acid and glycerol treatment.

Key Points

  • The aim was to evaluate the efficacy and tolerability of an intradermal biorejuvenation treatment for photoaging.
  • Retrospective uncontrolled pilot study
  • Included 17 Caucasian women aged 45-67
  • Used free hyaluronic acid and glycerol via two injection techniques over multiple sessions
  • Skin quality assessed with VISIA® CR, PRIMOS 3D, and LC-OCT
  • Significant reductions in visible spots and porphyrins observed using VISIA® CR
  • Trends toward improvement in wrinkles and UV spots noted
  • PRIMOS 3D showed qualitative improvements in most patients
  • LC-OCT revealed significant increase in stratum corneum thickness with positive remodeling trends

Cite This Study

Trovato et al. (2025) studied this question.

synapsesocial.com/papers/693624c34fa91c937236cc8fhttps://doi.org/10.3390/cosmetics12060273
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intradermal Treatment with a Hyaluronic Acid Complex Supplemented with Amino Acids and Antioxidant Vitamins Improves Cutaneous Hydration and Viscoelasticity in Healthy Subjects2024 · 26 citations
  2. 2Efficacy and Safety of Non-cross-Linked Hyaluronic Acid Injections for Facial Skin Biorevitalization: A Single-Center, Open-Label, Single-Arm, Uncontrolled, Post-marketing Study2025 · 6 citations
  3. 3Six-Month Changes in Periorbital and Perioral Wrinkles and Facial Skin Quality following Low-Cross-Linked Hyaluronic Acid2026
  4. 4Fractional carbon dioxide laser resurfacing combined with multilayer hyaluronic acid skinbooster injections for periocular, neck, and décolleté rejuvenation: A prospective multicenter observational interim analysis2026
  5. 5Bio‐Revitalizing <scp>SkinGlow</scp>: Assessing the Efficacy of Microcannula‐Assisted Treatment With Cohesive Polydensified Matrix Hyaluronic Acid With Glycerol (Belotero Revive) Through Ultrasound Elastography and Corneometry2025