What question did this study set out to answer?

This research aims to evaluate the antimicrobial and anticancer properties of Juniperus chinensis seed oil and its active component α-cedrol.

Antimicrobial and anticancer evaluation of Juniperus chinensis seed oil with molecular docking of α-cedrol–AKT1

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Analysis demonstrates antimicrobial and anticancer effects of Juniperus chinensis seed oil, suggesting a natural therapeutic source.

This research aims to evaluate the antimicrobial and anticancer properties of Juniperus chinensis seed oil and its active component α-cedrol.
Analyzed essential oil composition using GC-MS to identify major compounds.
Conducted antimicrobial testing against bacteria and fungi with inhibition zone measurements.
Performed cytotoxicity assays on MDA-MB-231 breast cancer cells and MCF-10A normal cells.
Executed molecular docking studies to assess binding affinity of α-cedrol to AKT-1 protein.
Identified 25 compounds in the seed oil, with α-pinene as the major component.
Demonstrated antimicrobial activity with inhibition zones against S. aureus, E. coli, and S. mutans.
Showed selective cytotoxicity for MDA-MB-231 cells with an IC50 of 38 µg/mL, without toxicity to normal cells.
Achieved strong binding affinity of α-cedrol to AKT-1 (-7.5 kcal/mol), indicating potential therapeutic effects.

Düz et al. (2026) studied this question.

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