Key result
Symptomatic women with CMD demonstrate a reduced mean MPRI of 1.71 versus asymptomatic controls.
Why the study?
Does noninvasive vasodilator stress cardiac MRI myocardial perfusion reserve index (MPRI) accurately detect coronary microvascular dysfunction compared to invasive coronary reactivity testing in women with suspected ischemia and no obstructive coronary artery disease?
Does noninvasive vasodilator stress cardiac MRI myocardial perfusion reserve index (MPRI) accurately detect coronary microvascular dysfunction compared to invasive coronary reactivity testing in women with suspected ischemia and no obstructive coronary artery disease?
Noninvasive cardiac MRI using the myocardial perfusion reserve index can effectively detect coronary microvascular dysfunction in women with suspected ischemia and no obstructive coronary artery disease.
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MPRI may support noninvasive CMD detection in women with suspected ischemia; hypothesis-generating and should not yet change practice.
Thomson et al. (2015) studied this question. Symptomatic women with coronary microvascular dysfunction had a mean MPRI of 1.71, significantly lower than the 2.23 in asymptomatic reference subjects (P < 0.0001).
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