July 1, 2008JAMA
Early Invasive vs Conservative Treatment Strategies in Women and Men With Unstable Angina and Non–ST-Segment Elevation Myocardial Infarction
Key result
An invasive strategy reduced death, MI, or rehospitalization in men and high-risk women, while low-risk women benefited more from a conservative treatment approach.
Why the study?
Does an early invasive treatment strategy reduce the composite of death, MI, or rehospitalization with ACS compared to a conservative strategy in women and men with NSTE ACS?
Population
Women and men with unstable angina and non-ST-segment elevation myocardial infarction (NSTE ACS)
Comparison
Early invasive treatment strategy vs Conservative treatment strategy
Authors
Discussion
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Member takes
Implication
Supports sex- and risk-stratified invasive strategy in NSTE ACS; challenges uniform guideline recommendations.
Structured PICO
Does an early invasive treatment strategy reduce the composite of death, MI, or rehospitalization with ACS compared to a conservative strategy in women and men with NSTE ACS?
P
Population
Women and men with unstable angina and non-ST-segment elevation myocardial infarction (NSTE ACS)
I
Intervention
Early invasive treatment strategy
C
Comparator
Conservative treatment strategy
O
Outcome
Composite end point of death, MI, or rehospitalization with ACScomposite
An early invasive strategy is beneficial for men and high-risk women with NSTE ACS, while a conservative strategy is supported for low-risk women.
Cite This Study
O’Donoghue et al. (2008) studied this question. An invasive strategy reduced death, MI, or rehospitalization in men and high-risk women, while low-risk women benefited more from a conservative treatment approach.