Key result
An early invasive strategy in women with acute coronary syndromes yielded a 28% odds reduction in death, MI, or rehospitalization (adjusted OR 0.72; 95% CI 0.47-1.11), similar to men.
Why the study?
Does an early invasive management strategy reduce the composite of death, myocardial infarction, or rehospitalization for ACS in women and men with acute coronary syndromes?
Population
2,220 patients with acute coronary syndromes enrolled across 169 centers in 9 countries in North America and…
Comparison
Early invasive strategy. All patients received… vs Early conservative strategy. All patients…
Design
RCT, randomized trial
Follow-up
6 months
Authors
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Supports early invasive strategy in women with ACS; confirms similar benefit to men in this RCT.
RCT (n=2,220)
randomized
Yes
Does an early invasive management strategy reduce the composite of death, myocardial infarction, or rehospitalization for ACS in women and men with acute coronary syndromes?
Effect estimate: adjusted OR 0.72 (95% CI 0.47-1.11)
p-value: p=0.60 for sex interaction
An early invasive strategy provides similar clinical benefit in both women and men with acute coronary syndromes, with enhanced benefit in women presenting with elevated troponin T levels.
Ruchira Glaser (2002) conducted an RCT in Acute Coronary Syndromes (n=2,220). Early invasive management strategy vs. Early conservative strategy was evaluated on Composite end point of death, myocardial infarction, or rehospitalization for ACS at 6 months (adjusted OR 0.72, 95% CI 0.47-1.11, p=0.60 for sex interaction). An early invasive strategy in women with acute coronary syndromes yielded a 28% odds reduction in death, MI, or rehospitalization (adjusted OR 0.72; 95% CI 0.47-1.11), similar to men.
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