Sex-related differences in baseline characteristics, management and outcome in patients with acute coronary syndrome without ST-segment elevation
Key result
Female sex is not associated with worse long-term all-cause mortality compared to men.
- HR 1.14
- 95% CI 0.89-1.47
- P=0.307
- n=812
Why the study?
Does female sex independently predict worse long-term mortality or lower rates of early invasive therapy in patients with NSTE-ACS?
Population
812 consecutive patients admitted for non-ST-segment elevation acute coronary syndrome between 2001 and 2004.
Comparison
Female sex vs Male sex
Design
Cohort
Follow-up
7 years
Authors
Discussion
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Member takes
Implication
Adjusted analyses indicate female sex is not an independent long-term mortality predictor in NSTE-ACS; leaves open whether treatment disparities affect outcomes.
Study Design
Type
Cohort (n=812)
Multicenter
No
Structured PICO
Does female sex independently predict worse long-term mortality or lower rates of early invasive therapy in patients with NSTE-ACS?
P
Population
812 consecutive patients admitted for non-ST-segment elevation acute coronary syndrome (NSTE-ACS) between 2001 and 2004 (342 women and 440 men with 7-year follow-up).
I
Intervention
Female sex
C
Comparator
Male sex
O
Outcome
All-cause mortality at 7-year follow-uphard clinical
Main Result
Effect estimate: HR 1.14 (95% CI 0.89-1.47)
Absolute Event Rate: 54.8% vs 39.3%
p-value: p=0.307
Women with NSTE-ACS receive less early invasive therapy primarily due to older age and renal insufficiency, but female sex itself is not an independent predictor of worse long-term mortality.
Cite This Study
Vogel et al. (2015) conducted a cohort in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) (n=812). Female sex vs. Male sex was evaluated on all-cause mortality (HR 1.14, 95% CI 0.89-1.47, p=0.307). Female sex was not associated with worse long-term all-cause mortality compared with men after adjustment for baseline characteristics and treatment (HR 1.14; 95% CI 0.89-1.47; p=0.307).