Key result
Greater device compression and smaller LAA ostial diameter on CT link to fewer LAAO complications.
Why the study?
Are specific preprocedural and postprocedural cardiac computed tomography (CCT) measurements associated with successful left atrial appendage occlusion (LAAO) implantation and early postimplant complications?
Cohort (n=165)
No
Are specific preprocedural and postprocedural cardiac computed tomography (CCT) measurements associated with successful left atrial appendage occlusion (LAAO) implantation and early postimplant complications?
Smaller preimplant left atrial appendage ostial dimensions and greater device compression on cardiac computed tomography are associated with fewer short-term complications following left atrial appendage occlusion.
CT-based LAAO sizing may reduce early complications; hypothesis-generating and requires prospective validation before practice change.
BACKGROUND: Left atrial appendage occlusion (LAAO) is an established alternative to long-term anticoagulation in patients with atrial fibrillation. Predicting successful LAAO device implantation with preplanning imaging studies, including cardiac computed tomography (CCT), remains a challenge. OBJECTIVES: The purpose of this study was to determine whether specific preprocedural and postprocedural CCT measurements are associated with successful LAAO implantation and can predict early postimplant complications. METHODS: This was a single-center retrospective study including 165 patients who underwent LAAO with Watchman FLX between November 2022 and January 2025 and had both preimplant and postimplant CCT. Adverse events including peri-device leak, device-related thrombus, or cerebrovascular events (transient ischemic attack/stroke) within 90 days were followed. RESULTS: ; P < 0.001). CONCLUSIONS: Smaller LAA ostial dimensions and greater device compression (postimplant area change) on CCT were associated with fewer complications post-LAAO. Favorable preimplant LAA ostial morphology seems to be oval shaped and of smaller size. These characteristics could be helpful in predicting better postimplant outcomes.
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Milutinovic et al. (2026) conducted a cohort in Atrial Fibrillation (n=165). Smaller LAA ostial dimensions and greater post-implant device compression on CCT vs. Larger LAA ostial dimensions and lesser device compression was evaluated on Composite of peri-device leak, device-related thrombus, and cerebrovascular events within 90 days (p=<0.001). Smaller pre-procedural minimum LAA ostial diameter and greater post-implant device compression on cardiac CT were associated with significantly fewer adverse events following left atrial appendage occlusion.
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