Integrative cross-tissue and spatially resolved single-cell profiling uncovers tumour-educated inflammatory remodelling of tissue-resident macrophage ecosystem with immunotherapeutic prognostic significance in pan-cancer.

Weikai Wang; Zibin Chen; Yuejiao Huang; Zhihao Hu; Peixin Zhu; Zhuoli Huang; Jingzhi Lv; Ziru Liao; Yuhui Zheng; Chen Wei; Baibing Guan; Yin Zeng; Xinyue Zhu; Yafei Yang; Guibo Li; Xin Jin; Xi Chen; Xiao Yang; Zikun Ma; Jianhua Yin

doi:10.1002/ctm2.70608

February 1, 2026

Integrative cross-tissue and spatially resolved single-cell profiling uncovers tumour-educated inflammatory remodelling of tissue-resident macrophage ecosystem with immunotherapeutic prognostic significance in pan-cancer.

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Key Points

The research aims to explore the inflammatory remodeling of tissue-resident macrophages across various cancer types and its implications for immunotherapy.
Developed a cross-tissue single-cell atlas focusing on tissue-resident macrophages.
Identified inflammatory TRM phenotype (iTRM) in multiple cancers.
Analyzed the interaction between TRMs and monocyte-derived macrophage lineages.
Discovered a conserved inflammatory TRM phenotype across pan-cancer.
Characterized a TRM inflammatory remodeling signature (TIR-Sig) with potential clinical relevance.
Highlighted the dynamic relationship between TRMs and monocyte-derived lineages.

Implication

Research uncovers inflammatory remodeling of tissue-resident macrophages in pan-cancer, suggesting prognostic implications for immunotherapy.

Abstract

Cross-tissue single-cell atlas of tissue-resident macrophages (TRMs). Identification of conserved inflammatory TRM phenotype (iTRM) in pan-cancer. Dynamic convergence of TRM and monocyte-derived macrophage lineages. TRM inflammatory remodelling signature (TIR-Sig) with clinical potential.

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Wang et al. (2026) studied this question.

synapsesocial.com/papers/698acad77c832249c30ba5e5 https://doi.org/10.1002/ctm2.70608

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Integrative cross-tissue and spatially resolved single-cell profiling uncovers tumour-educated inflammatory remodelling of tissue-resident macrophage ecosystem with immunotherapeutic prognostic significance in pan-cancer.

Key Points

Implication

Abstract

Discussion

Cite This Study

Integrative cross-tissue and spatially resolved single-cell profiling uncovers tumour-educated inflammatory remodelling of tissue-resident macrophage ecosystem with immunotherapeutic prognostic significance in pan-cancer.

Key Points

Implication

Abstract

Discussion

Cite This Study

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