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The research aims to characterize the diversity and developmental organization of tumor-associated macrophages (TAMs) across different cancers.

Pan-Cancer Single-Cell RNA Sequencing Analysis of Monocyte and Macrophage Lineages

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The research aims to characterize the diversity and developmental organization of tumor-associated macrophages (TAMs) across different cancers.
Utilized single-cell and spatial transcriptomic analysis of myeloid cells from healthy and tumor tissues.
Identified two main TAM lineages: C1QC+ resident and monocyte-derived lineages (SPP1+ and ISG15+).
Characterized THBS1+ immature myeloid cells as precursors to SPP1+ TAMs.
C1QC+ TAMs correlate with more favorable outcomes in cancer.
The THBS1+ MDSC-SPP1+ TAM axis is linked to poor survival and reduced efficacy of immunotherapy.
Refined understanding of myeloid cell development in the context of cancer.

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Analysis finds diverse monocyte and macrophage lineages in various cancers, suggesting implications for treatment outcomes.

Nguyen et al. (2026) studied this question.

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