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February 11, 2026Calcified Tissue InternationalOpen Access

Disproportionate Decline in Trabecular Bone Score Compared to Bone Mineral Density in Southeast Asian Patients with Thalassemia: A Matched Control Study

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Authors

CPChatlert PongchaiyakulNTNattiya TeawtrakulDTDaris Theerakulpisut

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Overview

Cross-sectional study shows reduced trabecular bone score in thalassemia patients, indicating lower bone quality versus controls.

Key Points

  • To assess the trabecular bone score alongside bone mineral density in thalassemia patients compared to healthy controls.
  • Cross-sectional study of thalassemia patients and healthy controls matched 2:1 by age and sex
  • Measurement of lumbar spine and femoral neck bone mineral density and trabecular bone score using dual-energy X-ray absorptiometry
  • Univariate and multivariate analyses to identify factors influencing trabecular bone score
  • Thalassemia patients had lower BMI, lumbar spine Z-score, femoral neck Z-score, and trabecular bone score than controls (all p < 0.001)
  • Only 24.4% of thalassemia patients had normal trabecular bone score compared to 77.9% of controls
  • Significant impairment in trabecular bone score observed in transfusion-dependent and non-transfusion-dependent thalassemia patients, independent of bone mineral density

Cite This Study

Pongchaiyakul et al. (2026) studied this question.

synapsesocial.com/papers/698be001058ab1890a13ba99https://doi.org/10.1007/s00223-026-01483-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bone turnover, areal BMD and bone microarchitecture by second-generation high-resolution peripheral quantitative tomography in transfusion-dependent thalassemia2024
  2. 2Magnitude of Bone Disease in Transfusion-Dependent and Non-Transfusion-Dependent β-Thalassemia Patients2024 · 2 citations
  3. 3Bone mineral density in a cohort of transfusion-dependent β-thalassemia (TDT) patients2024
  4. 4Trabecular bone score in the assessment of bone health in thalassemia major2025
  5. 5α- and β-Thalassemia Show Distinct Bone Microarchitectural Phenotypes in Southeast Asian Adults: Associations with Marrow Expansion Phenotype2026