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February 11, 2026International Journal of Cosmetic Science

Cosmetic potential of Ganoderma lucidum (Reishi) extract in a topical cream formulation

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Authors

SKSibel Dikmen KüçükDüzce ÜniversitesiPJPaul JabetAgroParisTechAGAnthony GrosoAgroParisTech

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Implication

Investigates Ganoderma lucidum extract's biological activities in a topical cream, suggesting its potential for cosmetic use.

Key Points

  • The study aims to evaluate the biological activities of Ganoderma lucidum extract and its suitability as a cosmetic ingredient.
  • Measured antioxidant capacity using a copper(II)‐based assay.
  • Assessed tyrosinase inhibition with human melanoma cells.
  • Tested cytotoxicity in human keratinocyte cells using the AlamarBlue® method.
  • Developed a topical cream through a multi‐phase emulsification technique and characterized its properties.
  • Conducted microbiological safety and preservative efficacy assessments according to regulations.
  • Reishi extract achieved 861 μmol TE/g in antioxidant activity and 30% tyrosinase inhibition.
  • Demonstrated a broader safety margin compared to argireline peptide and α‐arbutin, which were more cytotoxic.
  • The cream maintained a stable pH and viscosity without phase separation or integrity loss.
  • Microbiological analysis showed counts below regulatory limits, with effective preservative efficacy.

Cite This Study

Küçük et al. (2026) studied this question.

synapsesocial.com/papers/698c1bb8267fb587c655d987https://doi.org/10.1111/ics.70079
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Also Consider

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  1. 1Cosmeceutical and Dermatological Potential of Shiitake Mushroom ( Lentinula edodes ) Extract2026
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