What question did this study set out to answer?

To evaluate the effect of remote ischemic conditioning as an adjunct to intravenous thrombolysis in patients with acute ischemic stroke.

Effect of Remote Ischemic Conditioning on Outcomes for Acute Ischemic Stroke Patients Undergoing Alteplase Intravenous Thrombolysis: A Systematic Review and Meta-Analysis With Trial Sequential Analysis

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To evaluate the effect of remote ischemic conditioning as an adjunct to intravenous thrombolysis in patients with acute ischemic stroke.
Conducted a systematic review and meta-analysis of randomized controlled trials
Assessing the effects of remote ischemic conditioning in acute ischemic stroke patients
Evaluated risk of bias using the Cochrane tool
Performed trial sequential analysis to assess evidence certainty
Six randomized controlled trials included, with a total of 955 participants
No significant differences in stroke recurrence, hemorrhagic transformation, or 90-day mortality between RIC and control groups
RIC did not significantly improve functional or neurological outcomes, as measured by the modified Rankin Scale
Safety outcomes were comparable, indicating RIC is safe to use

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Systematic review and meta-analysis finds RIC does not improve outcomes in AIS patients treated with IVT, suggesting further investigation is needed.

Kurmasha et al. (2026) studied this question.

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Systematic review and meta-analysis finds RIC does not improve outcomes in AIS patients treated with IVT, suggesting further investigation is needed.