What question did this study set out to answer?

This research aims to enhance the skin absorption and follicular targeting of hydrophilic drugs using lipid-based nanocarriers and CO2 laser treatment.

February 11, 2026

Lipid-based nanocarriers coupled with CO2 laser-mediated drug delivery enhance skin penetration and hair follicle targeting.

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Authors

WLWoan-Ruoh LeeTaipei Medical University-Shuang Ho Hospital WCWei-Ling ChouMemorial Hospital of South Bend CHChien-Yu HsiaoMemorial Hospital of South Bend

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Implication

Preclinical investigation reveals enhanced skin delivery and follicular targeting of drugs using laser and nanoformulations, indicating a promising therapeutic approach.

Key Points

This research aims to enhance the skin absorption and follicular targeting of hydrophilic drugs using lipid-based nanocarriers and CO2 laser treatment.
Topical delivery of minoxidil and minocycline in nanocarrier forms.
Application of CO2 laser microporation on pig skin for improved drug absorption.
Assessment of drug accumulation in skin and hair follicles via confocal microscopy.
Use of an in vivo mouse model infected with Cutibacterium acnes to evaluate antibacterial effects.
Increased percutaneous absorption of minoxidil and minocycline using lipid-based nanocarriers.
7- and 9-fold increases in follicular uptake of minoxidil and minocycline, respectively, with laser treatment.
2-log reduction in bacterial colonies in infected skin following combined laser and nanocarrier treatment.

Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/698c1c65267fb587c655ed2c https://doi.org/10.1080/1061186x.2026.2629341

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Implication

Preclinical investigation reveals enhanced skin delivery and follicular targeting of drugs using laser and nanoformulations, indicating a promising therapeutic approach.

Lipid-based nanocarriers coupled with CO2 laser-mediated drug delivery enhance skin penetration and hair follicle targeting.

Discussion

Member takes

Implication

Key Points

Cite This Study

Lipid-based nanocarriers coupled with CO2 laser-mediated drug delivery enhance skin penetration and hair follicle targeting.

Discussion

Member takes

Implication

Key Points

Cite This Study

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