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The aim is to explore the role of viral helicases in replication and their inhibition as a therapeutic strategy.

February 11, 2026BiomoleculesOpen Access

Structure, Function and Inhibition of Helicases Involved in Virus Infection

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This review analyzes helicases' roles in viral infection, suggesting therapeutic implications through inhibition strategies.

The aim is to explore the role of viral helicases in replication and their inhibition as a therapeutic strategy.
Discussion of structural and biochemical data from various viral helicase superfamilies.
Comparison of helicase motifs and translocation models linked to ATP hydrolysis.
Analysis of helicase functions in genome replication, transcription, translation, and immune evasion.
Viral helicases are crucial for genome replication and immune evasion in viruses.
Different helicase superfamilies demonstrate varied substrate specificities and functions.
Targeting helicases with antiviral drugs shows potential but also presents challenges, including resistance mechanisms.

Sarvari et al. (2026) studied this question.

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