Key result
Viral helicase inhibitors decrease viral replication by preventing ATP hydrolysis, nucleic acid binding or release, or by disrupting helicase-cofactor interactions.
Population
Viral helicases
Design
Review
Authors
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Helicase inhibitors merit further preclinical antiviral development; leaves open clinical translation and human efficacy trials.
Viral helicases represent promising targets for antiviral drug development, with inhibitors acting through various mechanisms to disrupt viral replication.
Frick et al. (2006) conducted a review in Viral infections. Viral helicase inhibitors was evaluated. Viral helicase inhibitors decrease viral replication by preventing ATP hydrolysis, nucleic acid binding or release, or by disrupting helicase-cofactor interactions.
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