Muscle Regeneration on a Chip: Exercise-Induced Microtrauma and Optimal Mechanical Stimulation Regimen

Hongze Yin; Juan Zhang; Jing Zhou; Jia Chen; jiahao wang; Yue Wang; Na Liu; Tao Yue

doi:10.1039/d5lc00513b

January 1, 2026Lab on a Chip

Muscle Regeneration on a Chip: Exercise-Induced Microtrauma and Optimal Mechanical Stimulation Regimen

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Key Points

This research aims to understand how mechanical stimulation affects muscle regeneration following exercise-induced injuries.
Created a chip model to simulate muscle tissue interactions.
Induced microtrauma through exercise-like conditions.
Varying mechanical stimulation regimens were applied to the model for analysis.
Mechanical stimulation significantly improved muscle regeneration post microtrauma.
Optimal stimulation regimens showed increased muscle cell activity.
Tissue analysis indicated enhanced recovery and growth in stimulated samples.

Implication

Experimental investigation reveals optimal mechanical stimulation enhances muscle regeneration after exercise-induced microtrauma.

Abstract

Skeletal muscles, through their coordinated interaction with bones and joints, enable diverse human movements and are essential for maintaining normal physiological functions and overall health. However, the physiological state of...

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Cite This Study

Yin et al. (2026) studied this question.

synapsesocial.com/papers/698c1d1d267fb587c655fa14 https://doi.org/10.1039/d5lc00513b

View at Publisher

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Muscle Regeneration on a Chip: Exercise-Induced Microtrauma and Optimal Mechanical Stimulation Regimen

Key Points

Implication

Abstract

Discussion

Cite This Study

Muscle Regeneration on a Chip: Exercise-Induced Microtrauma and Optimal Mechanical Stimulation Regimen

Key Points

Implication

Abstract

Discussion

Cite This Study

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