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July 17, 2026PharmaceuticalsOpen Access

Mechanisms of Impaired Skeletal Muscle Regeneration and Therapeutic Approaches in Aging and Chronic Disease

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Authors

XLXia LiZZZihao ZhaoJYJiawen Yang

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Overview

This review discusses disruptions in muscle repair mechanisms in aging and chronic diseases, highlighting potential therapeutic approaches.

Key Points

  • The aim is to summarize mechanisms involved in impaired skeletal muscle regeneration associated with aging and chronic diseases.
  • Review of literature on muscle repair mechanisms and satellite cell activity.
  • Analysis of disruptions in regeneration due to various chronic diseases.
  • Evaluation of therapeutic interventions like exercise and bioactive molecules.
  • Aging and chronic diseases lead to impaired muscle repair and myogenic differentiation.
  • Chronic inflammation and metabolic dysfunction are common barriers to regeneration.
  • Multi-target strategies may surpass single-pathway therapies, with initial preclinical data showing promise.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a59c764a58755010b4723b3https://doi.org/10.3390/ph19071091
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