What question did this study set out to answer?

To determine whether deficits in olfactory identification correlate directly with in vivo amyloid-β accumulation across the spectrum of healthy aging, mild cognitive impairment, and Alzheimer's disease.

January 7, 2011Journal of Alzheimer s Disease

Olfactory Deficits and Amyloid-β Burden in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Aging: A PiB PET Study

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Authors

ABAlex Bahar‐FuchsDeakin University GCGaël ChételatUniversité Claude Bernard Lyon 1 VVVictor L. VillemagneEdith Cowan University

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Implication

Cross-sectional PET study reveals odor identification loss is uncoupled from amyloid-beta burden in mild cognitive impairment, suggesting independent disease mechanisms.

Key Points

To determine whether deficits in olfactory identification correlate directly with in vivo amyloid-β accumulation across the spectrum of healthy aging, mild cognitive impairment, and Alzheimer's disease.
Assessed 19 cognitively normal controls, 24 participants with amnestic mild cognitive impairment (aMCI), and 20 participants with Alzheimer's disease (N=63).
Administered an olfactory identification task and measured in vivo amyloid-β burden using Pittsburgh Compound B positron emission tomography (PiB PET).
Healthy control participants demonstrated superior olfactory identification scores and lower PiB binding relative to individuals with aMCI.
Olfactory identification performance correlated significantly with amyloid-β burden across pooled participants, but no significant relationship persisted within individual diagnostic groups.
Olfactory identification scores did not differ between aMCI participants classified as PiB-positive versus PiB-negative.

Cite This Study

Bahar‐Fuchs et al. (2011) studied this question.

synapsesocial.com/papers/698ca5f5244806f74a10723e https://doi.org/10.3233/jad-2010-100696

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Implication

Cross-sectional PET study reveals odor identification loss is uncoupled from amyloid-beta burden in mild cognitive impairment, suggesting independent disease mechanisms.

Olfactory Deficits and Amyloid-β Burden in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Aging: A PiB PET Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Olfactory Deficits and Amyloid-β Burden in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Aging: A PiB PET Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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