February 26, 2007Archives of Internal Medicine
Effect of Body Mass Index on Diagnostic and Prognostic Usefulness of Amino-Terminal Pro–Brain Natriuretic Peptide in Patients With Acute Dyspnea
Key result
Amino-terminal pro–brain natriuretic peptide concentrations are lower in overweight and obese patients, but maintain diagnostic and prognostic capacity in acute dyspnea.
Why the study?
Does body mass index affect the diagnostic and prognostic usefulness of NT-proBNP in patients with acute dyspnea?
Population
Patients with acute dyspnea (with and without acute heart failure)
Design
Cohort
Authors
Discussion
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Member takes
Implication
NT-proBNP retains diagnostic-prognostic utility across BMI in acute dyspnea; leaves open whether BMI-adjusted thresholds improve performance in prospective studies.
Structured PICO
Does body mass index affect the diagnostic and prognostic usefulness of NT-proBNP in patients with acute dyspnea?
P
Population
Patients with acute dyspnea (with and without acute heart failure)
I
Intervention
NT-proBNP measurement across different BMI categories
O
Outcome
Diagnostic and prognostic capacity of NT-proBNP
NT-proBNP retains its diagnostic and prognostic utility in patients with acute dyspnea across all BMI categories, despite absolute levels being lower in overweight and obese individuals.
Cite This Study
Antoni Bayés‐Genís (2007) studied this question. Amino-terminal pro–brain natriuretic peptide concentrations are lower in overweight and obese patients, but maintain diagnostic and prognostic capacity in acute dyspnea.