What question did this study set out to answer?

This research aims to understand how testosterone replacement therapy affects skeletal muscle metabolism during lifestyle interventions in older men with obesity and hypogonadism.

February 12, 2026SHILAP Revista de lepidopterologíaOpen Access

Testosterone plus lifestyle therapy improves skeletal muscle glycolysis in older men with obesity and hypogonadism

View Full Paper

Ask AI

Bookmark

Authors

VVViola ViolaMichael E. DeBakey VA Medical Center MAMarlene AguilarMichael E. DeBakey VA Medical Center MNMaria Liza Duremdes NavaMichael E. DeBakey VA Medical Center

Discussion

Member takes

Implication

Randomized trial shows that testosterone boosts glycolysis in older men with obesity and hypogonadism, suggesting effective metabolic adaptation.

Key Points

This research aims to understand how testosterone replacement therapy affects skeletal muscle metabolism during lifestyle interventions in older men with obesity and hypogonadism.
Randomized, double-blind trial with 83 men aged 65+
Participants received 26 weeks of lifestyle therapy with testosterone (LT+TRT) or placebo (LT+Pbo)
Targeted metabolomic analysis through serial biopsies of skeletal muscle
Glycolysis showed a significant increase in LT+TRT group compared to LT+Pbo (p=0.005)
Increased levels of glycolytic intermediates and lactate in LT+TRT
Positive correlation between glycolysis factor score and peak VO2 in LT+TRT (r=0.47, p=0.04)
Negative correlations with triglycerides and metabolic syndrome score in LT+TRT group

Cite This Study

Viola et al. (2026) studied this question.

synapsesocial.com/papers/698d6d445be6419ac0d522d5 https://doi.org/10.3389/fendo.2025.1719749

View Full Paper

Ask AI

Bookmark

Implication

Randomized trial shows that testosterone boosts glycolysis in older men with obesity and hypogonadism, suggesting effective metabolic adaptation.

Testosterone plus lifestyle therapy improves skeletal muscle glycolysis in older men with obesity and hypogonadism

Discussion

Member takes

Implication

Key Points

Cite This Study

Testosterone plus lifestyle therapy improves skeletal muscle glycolysis in older men with obesity and hypogonadism

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider