October 1, 2024Journal of the Endocrine SocietyOpen Access

7138 Testosterone Modulation of Muscle Transcriptome Profile During Intensive Lifestyle Intervention in Older Men With Obesity and Hypogonadism

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Authors

VVV ViolaMichael E. DeBakey VA Medical Center TSTannistha SamantaTwitter (United States)MNM Duremdes NavaMichael E. DeBakey VA Medical Center

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Implication

Randomized trial shows testosterone preserves muscle mass and bone mineral density during lifestyle intervention in older men with hypogonadism, indicating preservation of anabolic gene pathways.

Key Points

Testosterone replacement during lifestyle intervention preserved lean body mass and bone mineral density, reducing muscle mass loss during weight loss.
Lean body mass decreased less with testosterone versus placebo (-2% vs -4%, p=0.04), while hip bone mineral density was preserved (0.4% vs -1.1%).
In a randomized trial of older men with hypogonadism undergoing 26-week lifestyle therapy, serial muscle biopsies were assessed via transcriptomics.
Transcriptome profile findings show testosterone counters weight loss-induced downregulation of genes involved in skeletal muscle and bone anabolism.

Cite This Study

Viola et al. (2024) studied this question.

synapsesocial.com/papers/68e56381e2b3180350effe2f https://doi.org/10.1210/jendso/bvae163.1768

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Implication

Randomized trial shows testosterone preserves muscle mass and bone mineral density during lifestyle intervention in older men with hypogonadism, indicating preservation of anabolic gene pathways.

7138 Testosterone Modulation of Muscle Transcriptome Profile During Intensive Lifestyle Intervention in Older Men With Obesity and Hypogonadism

Discussion

Member takes

Implication

Key Points

Cite This Study

7138 Testosterone Modulation of Muscle Transcriptome Profile During Intensive Lifestyle Intervention in Older Men With Obesity and Hypogonadism

Discussion

Member takes

Implication

Key Points

Cite This Study

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