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February 12, 2026Open Access

Integrative multi-omics analysis of macrophage polarization-related genes in atherosclerosis development

JGJinying GaoJilin University PHPeng HuangOpen University of China YZYibing ZhangShanghai University

Key Points

To investigate the relationship between macrophage polarization-related genes and the development of atherosclerosis.
Integrated SMR (Summary Mendelian Randomization) analysis with transcriptomic validation.
Identified significant genes such as DNMT3A, DLGAP5, and SIRT6.
Conducted tissue-specific validation and GEO-based transcriptome analysis.
Identified key regulatory genes linked to macrophage polarization in atherosclerosis.
Evidence supports the significance of macrophage polarization in atherosclerosis pathogenesis.
Highlighting potential therapeutic avenues based on gene regulation.

Abstract

This study integrates SMR with transcriptomic validation to reveal causal links between macrophage polarization-related genes and atherosclerosis. Key genes DNMT3A, DLGAP5, and SIRT6 were identified as significant candidate regulatory factors. Tissue-specific validation and GEO-based transcriptome analysis provided robust evidence supporting these findings, highlighting the importance of macrophage polarization in atherosclerosis pathogenesis and offering new insights for therapeutic intervention.

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Cite This Study

Gao et al. (Mon,) studied this question.

synapsesocial.com/papers/698d6d445be6419ac0d52344 https://doi.org/https://doi.org/10.1186/s13148-026-02072-6

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