Key result
Expression levels of SYNJ2, NET1, FZD7, LCP2, HCK, GNB2, and PPP4C positively correlated with LVEF, while EIF4EBP1 negatively correlated with LVEF in atherosclerosis and MI mice models.
Why the study?
Macrophages are involved in all stages of cardiovascular diseases, but macrophages-related genes in the deterioration of atherosclerosis needed investigation.
Population
GEO datasets (GSE41571, GSE135055, GSE116250) and ApoE-/- and C57 atherosclerosis and MI mice models
Design
Bioinformatic analysis and preclinical animal validation study
Authors
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Highlights DEMRGs in atherosclerosis progression; leaves open causal roles and clinical utility pending validation.
Eight macrophage-related hub genes were identified and validated in mice models as potential biomarkers for atherosclerosis progression and MI-induced heart failure.
Zheng et al. (2022) studied Atherosclerosis and myocardial infarction. Macrophages-related genes was evaluated on Correlation with left ventricular ejection fraction (LVEF). Expression levels of SYNJ2, NET1, FZD7, LCP2, HCK, GNB2, and PPP4C positively correlated with LVEF, while EIF4EBP1 negatively correlated with LVEF in atherosclerosis and MI mice models.
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