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February 12, 2026Diagnostic PathologyOpen Access

SOX17/PAX8 dual immunohistochemical expression in the diagnosis of Müllerian carcinomas

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Authors

MMManar MoustafaMAMarwa Ahmed Mohamed AbdalrahmanHAHeba Mahmoud Abdelgeleel

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Overview

Immunohistochemical analysis distinguishes Müllerian carcinomas in a sample of gynecological cancers, implying effective diagnostic strategies.

Key Points

  • This research evaluates the effectiveness of SOX17 and PAX8 immunohistochemical markers in differentiating Müllerian carcinomas from non-gynecological cancers.
  • Analyzed 56 cases each of endometrial and ovarian cancers, plus 56 non-gynecological cancer cases using IHC for SOX17 and PAX8.
  • Conducted statistical analyses on immunohistochemical expression.
  • Compared marker expression levels between cancer types.
  • Endometrial carcinomas with PAX8-high/SOX17-high expression strongly indicated endometrioid histology (90% vs. 68.8%, p = 0.04).
  • In ovarian cancers, 78.9% displayed high PAX8 expression, while SOX17 showed more variability (47.4% high).
  • Double-negative PAX8/SOX17 status excluded Müllerian origin with 100% specificity for metastases from colorectal, breast, and pulmonary tumors.

Cite This Study

Moustafa et al. (2026) studied this question.

synapsesocial.com/papers/698d6d8c5be6419ac0d5287chttps://doi.org/10.1186/s13000-026-01746-2
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Also Consider

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  1. 1A comprehensive analysis of SOX17 expression by immunohistochemistry in human epithelial tumors, with an emphasis on gynecologic tumors2024 · 7 citations
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