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July 26, 2026International Journal of Gynecological Pathology

SOX2 Can Support a Diagnosis of PiMHEC With Rare to Absent Ghost Cells and Can Distinguish PiMHEC From Its Most Problematic Mimickers

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Authors

JXJin XuPWPaul Weisman

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Overview

Randomized trial evaluated SOX2 to confirm PiMHEC diagnosis, indicating its significance against mimickers.

Key Points

  • This research aims to assess SOX2 immunohistochemistry as a diagnostic tool for pilomatrix-like high-grade endometrioid carcinoma (PiMHEC).
  • Evaluated SOX2 expression in 26 cases of PiMHEC and problematic mimickers.
  • Analyzed non-PiMHEC FIGO grade 3 endometrioid carcinomas with aberrant beta-catenin and undifferentiated/dedifferentiated EMCA.
  • Employing a tissue microarray with 84 endometrioid carcinoma cases for comparison.
  • All 26 PiMHEC cases showed robust SOX2 positivity, confirming its diagnostic value.
  • None of the non-PiMHEC FIGO grade 3 EMCAs with aberrant beta-catenin expressed SOX2.
  • Only 5 of 84 EMCA cases exhibited SOX2 positivity, indicating that SOX2 effectively distinguishes PiMHEC from mimickers.

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6a65a9f3d3aea3239cd794bdhttps://doi.org/10.1097/pgp.0000000000001197
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