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February 12, 2026Scientific ReportsOpen Access

Development of a controlled ex vivo human skin platform for quantitative evaluation of age-related functional biomarkers following application of topical treatments

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Authors

XZXinge ZhangNANasri A. AtallaERElia Rodriguez

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Overview

Controlled ex vivo model assesses age-related biomarkers in human skin, suggesting improved evaluation of topical treatments.

Key Points

  • The research aims to develop a human skin model to study age-related cellular changes and the effects of topical treatments.
  • Developed an ex vivo human skin explant platform using tissues from donors of different ages and skin types.
  • Applied standardized UVA and UVB doses to induce photodamage for analysis of topical treatments' effects.
  • Conducted a four-week case study evaluating the ND-ZnO formulation on a single donor.
  • ND-ZnO and NAC treatments reduced p16^INK4a and p53 levels, indicating decreased cellular senescence.
  • ND-ZnO and exosomes lowered IL-1β expression, a biomarker for inflammation.
  • Histological analysis showed improved epidermal structure and reduced inflammation in ND-ZnO treated skin.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/698d6e7b5be6419ac0d54373https://doi.org/10.1038/s41598-026-38877-x
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