Ruthenium-catalyzed site-selective C-H allylation of aryl ketones using Morita-Baylis-Hillman alcohols: access to α-benzyl acrylates

Hemanga Bhattacharyya; Sharajit Saha; Srikrishna Khamrai; Kshitiz Verma; Sajal Roy; Tharmalingam Punniyamurthy

doi:10.1039/d5cc07391j

January 1, 2026Chemical Communications

Ruthenium-catalyzed site-selective C-H allylation of aryl ketones using Morita-Baylis-Hillman alcohols: access to α-benzyl acrylates

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Key Points

This research aims to develop a ruthenium-catalyzed method for site-selective C-H allylation of aryl ketones.
Utilized ruthenium as a catalyst for C–H allylation
Applied Morita-Baylis-Hillman alcohols as reagents
Explored substrate scope and functional group tolerance
Successfully synthesized α-benzyl acrylates from aryl ketones
Demonstrated high selectivity in C-H bond activation
Showed effective late-stage diversification to substituted indanes

Implication

Catalytic processes achieve selective C-H allylation in aryl ketones, indicating new synthesis methods for acrylates.

Abstract

Ru-catalyzed weak-chelation-assisted site-selctive C–H allylation of aryl ketones has been accomplished with MBH alcohols to furnish α-benzyl acrylates. Substrate scope, functional group tolerance, and late-stage diversification to substituted indanes and...

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Cite This Study

Bhattacharyya et al. (2026) studied this question.

synapsesocial.com/papers/698d6e925be6419ac0d545b0 https://doi.org/10.1039/d5cc07391j

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Ruthenium-catalyzed site-selective C-H allylation of aryl ketones using Morita-Baylis-Hillman alcohols: access to α-benzyl acrylates

Key Points

Implication

Abstract

Discussion

Cite This Study

Ruthenium-catalyzed site-selective C-H allylation of aryl ketones using Morita-Baylis-Hillman alcohols: access to α-benzyl acrylates

Key Points

Implication

Abstract

Discussion

Cite This Study

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