An unprecedented Ru(II)-catalyzed deoxygenative, site-selective formal [3 + 1 + 2] benzannulation reaction for the efficient synthesis of highly substituted benzene molecules is reported. This reaction between allyl alcohols and acetylenedicarboxylate esters proceeds via cascade C–H activation, consecutive double migratory insertion with alkynes, and cycloaromatization followed by an unusual specific C–C triple bond cleavage.
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Dethe et al. (2024) studied this question.
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