What question did this study set out to answer?

The aim is to summarize current knowledge on DNA methylation's role in reproductive functions in mammalian species.

February 12, 2026GenesOpen Access

DNA Methylation in the Ovary and Uterus of Mammalian Animal Models: Implications for Reproductive Function

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This review examines DNA methylation effects on reproductive function in mammalian models, indicating potential for fertility applications.

The aim is to summarize current knowledge on DNA methylation's role in reproductive functions in mammalian species.
Review of existing literature on DNA methylation in ovarian development and uterine function.
Focus on the fluctuations in methylation and demethylation processes.
Highlights the involvement of specific enzymes such as DNMTs and TETs.
Demonstrates the importance of DNA methylation in regulating gene expression and maintaining genome stability in reproductive tissues.
Identifies key roles for methylation in folliculogenesis, oocyte maturation, and steroidogenesis.
Suggests potential applications for fertility preservation based on understanding these epigenetic mechanisms.

Serej et al. (2026) studied this question.

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This review examines DNA methylation effects on reproductive function in mammalian models, indicating potential for fertility applications.