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October 10, 2025Annual Review of Animal Biosciences

Roles and Regulation of DNA Methylation in Early Mammalian Development

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Authors

EIElena IvanovaGKGavin Kelsey

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Overview

Research shows that DNA methylation impacts genomic imprinting in mammals, suggesting implications for assisted reproduction.

Key Points

  • DNA methylation plays a crucial role in mammalian development, influencing processes like gametogenesis.
  • It shows significant changes during critical stages of development, including germ-cell specification and preimplantation.
  • Using the mouse model, scientists have developed insights into how methylation reacts to environmental influences.
  • The study of methylation across species reveals unexpected patterns that are vital for advancing assisted reproduction techniques.

Cite This Study

Ivanova et al. (2025) studied this question.

synapsesocial.com/papers/68e8619c7ef2f04ca37e43cdhttps://doi.org/10.1146/annurev-animal-030424-085652
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1DNA methylation patterns and epigenetic memory2002 · 7,209 citations
  2. 2Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development1987 · 1,092 citations
  3. 3The genetic basis for DNA methylation variation across tissues and development2025
  4. 4DNA Methylation in the Ovary and Uterus of Mammalian Animal Models: Implications for Reproductive Function2026 · 1 citations
  5. 5Epigenetic relay: Polycomb-directed DNA methylation in mammalian development2025 · 5 citations