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September 17, 2025Open Access

The genetic basis for DNA methylation variation across tissues and development

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Authors

JRJonathan RosenskiOSOfra SabagEME.M. Marcus

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Overview

Research uncovers how genetic variation shapes the epigenome, revealing links between dna methylation and development.

Key Points

  • DNA methylation is significantly influenced by genetic variation across various tissues and development stages.
  • In mice, thousands of differentially methylated regions are linked to specific genetic sequence polymorphisms.
  • The analysis of 39 purified human cell types revealed over 33,000 regions where common SNPs impact methylation.
  • This research highlights the interplay between genetic variations and epigenetic regulation across species.

Cite This Study

Rosenski et al. (2025) studied this question.

synapsesocial.com/papers/68d45e4431b076d99fa5e2fehttps://doi.org/10.1101/2025.09.15.675351
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Roles and Regulation of DNA Methylation in Early Mammalian Development2025
  2. 2Interplay of the Genetic Variants and Allele Specific Methylation in the Context of a Single Human Genome Study2025 · 1 citations
  3. 3Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development1987 · 1,092 citations
  4. 4DNA methylation patterns and epigenetic memory2002 · 7,209 citations
  5. 5A longitudinal study of epigenetic variation in twins2010 · 329 citations