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February 12, 2026Journal of the American Heart AssociationOpen Access

Associations Between Hemodynamics, Shape and Atherosclerosis in M1 of Middle Cerebral Artery: Insights From 4‐Dimensional Flow Magnetic Resonance Imaging in Patients With Ischemic Stroke

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Authors

WSWeixu SuPJPeirong JiangYZYanping Zheng

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Overview

A cross-sectional study explores plaque formation in patients with ischemic stroke, indicating hemodynamic factors impact stroke risk.

Key Points

  • This study aims to investigate how M1 artery shape and hemodynamic factors relate to plaque distribution and stroke risk.
  • Cross-sectional study involving 100 patients with unilateral ischemic stroke
  • Assessment of wall shear stress (TAWSS) and oscillatory shear index (OSI) at various artery points
  • Comparison of measurements between stroke-affected and non-stroke sides in patients with curved M1 segments
  • Curved M1 arteries showed lower inner-wall TAWSS and higher OSI compared to outer-wall and straight sections
  • Plaque areas near curved sections had greater wall thickness and OSI but lower TAWSS
  • In curved M1, stroke sides had reduced inner-wall TAWSS and elevated outer-wall OSI compared to non-stroke sides

Cite This Study

Su et al. (2026) studied this question.

synapsesocial.com/papers/698d6eca5be6419ac0d5496chttps://doi.org/10.1161/jaha.125.044697
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