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February 12, 2026Journal of Intensive CareOpen Access

Pharmacological profiles and mechanism of action of remimazolam for ICU sedation

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Authors

KMKenichi MasuiYokohama City University

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Implication

This research demonstrates remimazolam’s potential as an ICU sedative, indicating its rapid metabolism and effects on sedation dynamics.

Key Points

  • Investigate the pharmacological characteristics and sedation mechanisms of remimazolam for ICU applications.
  • Examined remimazolam's metabolism by carboxylesterase 1 in the liver.
  • Compared pharmacokinetics with propofol and effects on sedation levels.
  • Evaluated dosing effects related to patient characteristics such as sex and body mass index.
  • Remimazolam has a shorter action duration compared to other sedatives.
  • Accidental accumulation during prolonged infusion can lead to delayed emergence.
  • Dosing adjustments are needed based on sex, weight, and physical status of patients.

Cite This Study

Kenichi Masui (2026) studied this question.

synapsesocial.com/papers/698d6f0d5be6419ac0d550e2https://doi.org/10.1186/s40560-026-00858-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The risk of delirium after sedation with propofol or midazolam in intensive care unit patients2024 · 32 citations
  2. 2Successful reversal of remimazolam anesthesia in a “cannot intubate, can ventilate” situation: a case report2023 · 6 citations
  3. 3Comparison of postoperative nausea and vomiting between remimazolam and propofol: a propensity score-matched, retrospective, observational, single-center cohort study2022 · 37 citations
  4. 4Cannot Intubate???Cannot Ventilate and Difficult Intubation Strategies: Results of a Canadian National Survey2005 · 117 citations
  5. 5Efficacy and safety of analgosedation with dexmedetomidine in critically ill mechanically ventilated children: a systematic review and meta-analysis of randomized controlled trials2025 · 2 citations