What question did this study set out to answer?

This meta-analysis aimed to evaluate the prognostic significance of bone marrow plasma cell percentage in patients with systemic light-chain amyloidosis.

February 12, 2026European Journal Of Haematology

Prognostic Impact of Bone Marrow Plasma Cell Percentage in Patients With Systemic Light‐Chain Amyloidosis: A Systematic Review and Meta‐Analysis

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Authors

ZNZi‐Yuan Nie YAYilimunuer AihemaitiPeople's Hospital of Xinjiang Uygur Autonomous Region FMFan‐Qiao MengArmy Medical University

Discussion

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Implication

Meta-analysis demonstrates poorer survival outcomes in patients with elevated bone marrow plasma cell percentage in AL amyloidosis, suggesting improved risk stratification.

Key Points

This meta-analysis aimed to evaluate the prognostic significance of bone marrow plasma cell percentage in patients with systemic light-chain amyloidosis.
Systematic search of multiple databases for studies up to September 2025.
Inclusion of 10 studies with a total of 5322 patients.
Assessment of association between BMPC% ≥ 10% and survival outcomes.
Calculation of pooled hazard ratios for overall survival and progression-free survival.
BMPC% ≥ 10% was associated with a pooled hazard ratio of 1.35 for overall survival.
Patients with BMPC% ≥ 10% had a mean overall survival reduction of 31.79 months.
The pooled hazard ratio for progression-free survival was 1.63.
Significant heterogeneity in studies was noted, with publication bias present.

Cite This Study

Nie et al. (2026) studied this question.

synapsesocial.com/papers/698d6f5f5be6419ac0d55310 https://doi.org/10.1111/ejh.70138

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Implication

Meta-analysis demonstrates poorer survival outcomes in patients with elevated bone marrow plasma cell percentage in AL amyloidosis, suggesting improved risk stratification.

Prognostic Impact of Bone Marrow Plasma Cell Percentage in Patients With Systemic Light‐Chain Amyloidosis: A Systematic Review and Meta‐Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Prognostic Impact of Bone Marrow Plasma Cell Percentage in Patients With Systemic Light‐Chain Amyloidosis: A Systematic Review and Meta‐Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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