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March 29, 2014JAMA621 citationsOpen Access

Validation of the Atherosclerotic Cardiovascular Disease Pooled Cohort Risk Equations

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PMPaul MuntnerLCLisandro D. ColantonioMCMary Cushman

Key Result

The ACC/AHA Pooled Cohort risk equations were well calibrated for predicting 5-year atherosclerotic CVD risks in US adults, demonstrating moderate to good discrimination.

Key Points

  • This research aims to validate the Atherosclerotic Cardiovascular Disease Pooled Cohort Risk Equations for predicting 5-year risk of atherosclerotic cardiovascular disease.
  • Analyzed a cohort of US adults considered for statin initiation based on risk equations.
  • Compared observed and predicted 5-year atherosclerotic cardiovascular disease risks.
  • Observed and predicted risks were similar, indicating good calibration in the target population.
  • The risk equations demonstrated moderate to good discrimination in identifying high-risk individuals.

Structured PICO

Do the ACC/AHA Pooled Cohort risk equations accurately predict 5-year atherosclerotic CVD risks in US adults considered for statin initiation?

P
Population
US adults for whom statin initiation is considered based on the ACC/AHA Pooled Cohort risk equations
I
Intervention
ACC/AHA Pooled Cohort risk equations
O
Outcome
5-year atherosclerotic CVD riskshard clinical

The ACC/AHA Pooled Cohort risk equations are well calibrated and demonstrate moderate to good discrimination for predicting 5-year atherosclerotic CVD risk in US adults.

Abstract

In this cohort of US adults for whom statin initiation is considered based on the ACC/AHA Pooled Cohort risk equations, observed and predicted 5-year atherosclerotic CVD risks were similar, indicating that these risk equations were well calibrated in the population for which they were designed to be used, and demonstrated moderate to good discrimination.

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Cite This Study

Muntner et al. (2014) studied this question. The ACC/AHA Pooled Cohort risk equations were well calibrated for predicting 5-year atherosclerotic CVD risks in US adults, demonstrating moderate to good discrimination.

synapsesocial.com/papers/698e30bad024768a810c7892https://doi.org/10.1001/jama.2014.2630
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