Key result
ACC/AHA Pooled Cohort equations accurately predict 5-year atherosclerotic CVD risk in US adults.
Why the study?
Do the ACC/AHA Pooled Cohort risk equations accurately predict 5-year atherosclerotic CVD risks in US adults considered for statin initiation?
Do the ACC/AHA Pooled Cohort risk equations accurately predict 5-year atherosclerotic CVD risks in US adults considered for statin initiation?
The ACC/AHA Pooled Cohort risk equations are well calibrated and demonstrate moderate to good discrimination for predicting 5-year atherosclerotic CVD risk in US adults.
Supports PCE use for 5-year ASCVD risk estimation in statin candidates; extends validation to contemporary US cohorts.
In this cohort of US adults for whom statin initiation is considered based on the ACC/AHA Pooled Cohort risk equations, observed and predicted 5-year atherosclerotic CVD risks were similar, indicating that these risk equations were well calibrated in the population for which they were designed to be used, and demonstrated moderate to good discrimination.
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Muntner et al. (2014) studied this question. The ACC/AHA Pooled Cohort risk equations were well calibrated for predicting 5-year atherosclerotic CVD risks in US adults, demonstrating moderate to good discrimination.
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