Key result
Charge immobilization during repolarization was 53% for wild-type hH1a and 31% for lid-modified ICM-hH1aMTSET, indicating the role of domain IV-S4 movement.
Population
Fused tsA201 cells expressing wild-type human heart sodium channel (hH1a) or mutant (ICM-hH1a)
Comparison
Intracellular perfusion with MTSET and… vs Wild-type hH1a
Design
Preclinical
Authors
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Domain IV-S4 movement limits cardiac NaV1.5 charge immobilization; hypothesis-generating for gating kinetics, leaves clinical translation open.
Movement of domain IV-S4 is the rate-limiting step during repolarization in human heart sodium channels, contributing to charge immobilization independent of inactivation lid binding.
Sheets et al. (2000) studied this question. Charge immobilization during repolarization was 53% for wild-type hH1a and 31% for lid-modified ICM-hH1aMTSET, indicating the role of domain IV-S4 movement.
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