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To explore the role of MeCP2 in the nucleus accumbens and its effect on cocaine-seeking behavior.

MeCP2 in the nucleus accumbens regulates operant cocaine self-administration and effort-based responding

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To explore the role of MeCP2 in the nucleus accumbens and its effect on cocaine-seeking behavior.
Targeted MeCP2 knockdown in the nucleus accumbens of mice.
Conducted a cocaine self-administration paradigm to assess cocaine intake.
Performed a conditioned place preference (CPP) test to evaluate cocaine-conditioned reward.
shMeCP2 mice showed significantly higher cocaine intake and increased lever presses during self-administration.
Increased effort-based responding for cocaine was observed in shMeCP2 mice.
No significant differences in CPP scores between groups were found, indicating similar conditioned reward responses.

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Operant cocaine self-administration influenced by MeCP2 in the nucleus accumbens, suggesting its role in addiction mechanisms.

Bae et al. (2026) studied this question.

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