Transperineal Versus Transrectal Biopsy for Prostate Cancer Diagnosis: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Giancarlo Marra; Francesca Bazzurro; Alessandro Dematteis; Alberto Sasia; Paolo Gardois; Alessio Venturi; Umberto Merani; Giorgio Calleris; Alessandro Marquis; Hazem Orabi; Akihiro Matsukawa; Daniela Zugna; Shahrokh F. Shariat; Guillaume Ploussard; Alberto Briganti; Giorgio Gandaglia; P. Rajwa; Lorenzo Richiardi; Paolo Gontero

doi:10.1016/j.euo.2026.01.009

Key Points

The study aims to compare the effectiveness and safety of transperineal biopsy versus transrectal biopsy for diagnosing prostate cancer.
Conducted a systematic review of randomized controlled trials
Analyzed infection rates, discomfort, and detection rates
Compared outcomes between transperineal biopsy (TP-Bx) and transrectal biopsy (TR-Bx)
TP-Bx showed lower infection rates without the need for antibiotics
Detection rates for prostate cancer were equivalent between TP-Bx and TR-Bx
TP-Bx resulted in minimal increases in discomfort and procedure time

Implication

A systematic review compares transperineal and transrectal biopsy methods for prostate cancer, suggesting a preferred approach due to lower complications.

Discussion

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Cite This Study

Marra et al. (2026) studied this question.

synapsesocial.com/papers/698ebeb185a1ff6a93015ff7 https://doi.org/10.1016/j.euo.2026.01.009

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Transperineal Versus Transrectal Biopsy for Prostate Cancer Diagnosis: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Key Points

Implication

Discussion

Cite This Study

Transperineal Versus Transrectal Biopsy for Prostate Cancer Diagnosis: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Key Points

Implication

Discussion

Cite This Study

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