What question did this study set out to answer?

This research aims to evaluate treatment patterns and outcomes related to first-line Bruton tyrosine kinase inhibitors in elderly patients with chronic lymphocytic leukemia.

February 13, 2026Expert Review of Hematology2 citations

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Real-world treatment utilization patterns, discontinuation and healthcare resource utilization of first-line Bruton tyrosine kinase inhibitors among elderly patients ≥65 years in chronic lymphocytic leukemia

SASikander AilawadhiWinnMed SCSwetha ChallagullaNational University of Misiones PCPo-Ya ChuangUniversidad Real

Key Points

This research aims to evaluate treatment patterns and outcomes related to first-line Bruton tyrosine kinase inhibitors in elderly patients with chronic lymphocytic leukemia.
Real-world study using patient data
Comparison between zanubrutinib, acalabrutinib, and ibrutinib
Assessment of time to treatment discontinuation (TTD)
Evaluation of healthcare resource utilization (HCRU)
Zanubrutinib showed longer time to treatment discontinuation (TTD) compared to acalabrutinib and ibrutinib.
Lower rates of treatment discontinuation were observed with zanubrutinib.
Zanubrutinib was associated with decreased healthcare resource utilization (HCRU).

Abstract

This real-world study demonstrated that zanubrutinib was associated with longer TTD, lower discontinuation rates, and less HCRU compared to acalabrutinib or ibrutinib in older CLL patients aged ≥65 years.

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Real-world treatment utilization patterns, discontinuation and healthcare resource utilization of first-line Bruton tyrosine kinase inhibitors among elderly patients ≥65 years in chronic lymphocytic leukemia

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Abstract

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