Case report highlights the importance of retesting IgA levels to prevent misdiagnosis of multiple myeloma.
When the IgA test results contradict the serum globulin levels, attention should be paid to the hook effect. Laboratory personnel should obtain the true level of IgA through sample dilution retesting to avoid misdiagnosis and missed diagnosis of multiple myeloma.
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Li et al. (2026) studied this question.
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