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This study examines how the time of acute ischemic stroke onset affects the severity of symptoms at admission.

February 13, 2026Journal of Central Nervous System DiseaseOpen Access

The Influence of Circadian Onset Time on Admission Severity in Acute Ischemic Stroke: A Retrospective Cohort Study

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This study examines how the time of acute ischemic stroke onset affects the severity of symptoms at admission.
Conducted a multicenter retrospective cohort study across 36 hospitals in Shenzhen, China.
Included 14,048 patients diagnosed with acute ischemic stroke between January 2022 and May 2024.
Classified stroke onset time into Morning, Afternoon, Evening, and Night periods.
Measured admission severity using the NIHSS score and mRS score.
Employed multivariable ordinal logistic and linear regression models for analysis.
Morning onset associated with lower NIHSS scores (aOR = 0.88; P < .001) and lower mRS scores (aOR = 0.81; P < .001).
Night onset linked to higher NIHSS scores (aOR = 1.20; P < .001) and higher mRS scores (aOR = 1.25; P < .001).
The associations remained consistent across various clinical subgroups but weakened in certain conditions like coronary artery disease.

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Implication

Retrospective cohort study reveals the connection between stroke onset time and admission severity in acute ischemic stroke patients, indicating implications for clinical management.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/698ebf3485a1ff6a93016697 https://doi.org/10.1177/11795735261421368

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Implication

Retrospective cohort study reveals the connection between stroke onset time and admission severity in acute ischemic stroke patients, indicating implications for clinical management.

The Influence of Circadian Onset Time on Admission Severity in Acute Ischemic Stroke: A Retrospective Cohort Study

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Discussion

Implication

Cite This Study

The Influence of Circadian Onset Time on Admission Severity in Acute Ischemic Stroke: A Retrospective Cohort Study

Key Points

Discussion

Implication

Cite This Study

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