What question did this study set out to answer?

To examine how postmortem intervals affect quantitative MRI values in both unfixed and fixed swine brains.

February 14, 2026Magnetic Resonance in Medical Sciences0 citationsOpen Access

Effects of Postmortem Intervals on Quantitative MRI in Unfixed and Fixed Swine Brain: Implications for Ex Vivo MRI Applications

LWL Wang NONaoya Oishi SUShin-ichi Urayama

Key Points

To examine how postmortem intervals affect quantitative MRI values in both unfixed and fixed swine brains.
Conducted quantitative MRI on swine brains with varying postmortem intervals.
Analyzed T1 relaxation time changes due to fixation and PMI.
Compared inter-sample variability between fixed and unfixed brains.
PMI significantly affects T1 relaxation times in unfixed brain samples.
Fixation reduces the apparent effects of PMI on qMRI values.
Rank order of PMI effects can still be retrieved from fixed brains.

Abstract

PMI exerts the most robust effects on T1. Fixation has a significant impact on qMRI values, mitigating the apparent PMI effect and increasing the inter-sample variability. However, it is still possible to retrieve the PMI effects from fixed brain at the level of rank order, providing practical guidance for further ex vivo qMRI studies on PMI.

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