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February 14, 2026BMJ OpenOpen Access

Tofacitinib in rheumatoid arthritis: a German real-world study with focus on treatment changes, effectiveness and patient-reported outcomes (ESCALATE-RA)

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Authors

KKKlaus KruegerFBF. BehrensJBJan Brandt-Juergens

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Overview

Non-interventional study evaluates treatment changes and patient outcomes with tofacitinib in rheumatoid arthritis, indicating key predictors.

Key Points

  • The study aims to identify predictors of treatment changes and assess the effectiveness and patient-reported outcomes of tofacitinib in rheumatoid arthritis.
  • Non-interventional study involving 1518 patients with rheumatoid arthritis from Germany.
  • Documented treatment changes over 24 months from the initiation of tofacitinib therapy.
  • Analysis of primary outcomes using Cox proportional hazards models to assess treatment change predictors.
  • Key factors for therapy changes were lack of efficacy (HR 3.30) and intolerance (HR 4.43).
  • Higher patient satisfaction was linked to a lower likelihood of treatment changes (HR 0.82).
  • Tofacitinib drug survival estimated at 48% at study's end.
  • Improvements in disease activity, functional ability, pain, and quality of life were observed.
  • 63.9% of patients experienced adverse events, aligned with known safety profile.

Cite This Study

Krueger et al. (2026) studied this question.

synapsesocial.com/papers/699010ce2ccff479cfe57037https://doi.org/10.1136/bmjopen-2024-096952
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tofacitinib Monotherapy in Rheumatoid Arthritis: Clinical Trials and Real-World Data Contextualization of Patients, Efficacy, and Treatment Retention2024 · 1 citations
  2. 2Real‐World Data of Tofacitinib Versus Tumor Necrosis Factor Inhibitors in Taiwanese Patients With Rheumatoid Arthritis From a Drug‐Based Cohort Study2026
  3. 3Treatment Patterns and Effectiveness of Tofacitinib in Patients Initiating Therapy for Rheumatoid Arthritis: Results From the CorEvitas Rheumatoid Arthritis Registry2024 · 1 citations
  4. 4Real-world evidence of tofacitinib in rheumatoid arthritis patients in Spain2022 · 8 citations
  5. 5Tofacitinib as a means of optimizing the treatment of rheumatoid arthritis at the outpatient stage (clinical cases)2024 · 1 citations