Prospective Study of Body Mass Index and Risk of Stroke in Apparently Healthy Women
Why the study?
Does obesity (BMI ≥30 kg/m2) increase the risk of incident stroke in apparently healthy women compared to BMI <25 kg/m2?
Population
Apparently healthy women participating in the Women's Health Study
Comparison
Obesity (BMI ≥30 kg/m2) vs BMI <25 kg/m2
Design
Cohort
Follow-up
mean 10 years
Authors
Discussion
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Member takes
Implication
Obesity associated with higher total/ischemic stroke risk in healthy women; extends male data but leaves causality open for trials.
Structured PICO
Does obesity (BMI ≥30 kg/m2) increase the risk of incident stroke in apparently healthy women compared to BMI <25 kg/m2?
P
Population
Apparently healthy women participating in the Women's Health Study
I
Intervention
Obesity (BMI ≥30 kg/m2)
C
Comparator
BMI <25 kg/m2
O
Outcome
Incident stroke (total, ischemic, and hemorrhagic)hard clinical
In apparently healthy women, obesity is a strong risk factor for total and ischemic stroke, though this risk is largely mediated by hypertension, diabetes, and elevated cholesterol.
Cite This Study
Kurth et al. (2005) studied this question.