A simple, ligand-free Cu(OH)2-catalyzed methoxylation of aryl halides

To develop a simple, rapid and cheap catalytic method for methoxylation of aryl halides for late-stage functionalization and demonstrate its utility in isotopic labelling. A ligand-free, microwave-assisted method for methoxylation of aryl halides using copper(II) hydroxide as catalyst has been explored. The new method is simple and cheap, afforded synthetically useful yields in some cases, but does not seem to give generally higher yields in more substituted systems. The viability of isotopic labelling using the method has been demonstrated by 13 C-incorporation at the methoxy group.