IV Tenecteplase Before Thrombectomy Compared With Thrombectomy Alone in Patients With Stroke Due to a Large Vessel Occlusion

Key Points

The study aims to evaluate the effectiveness of IV tenecteplase when administered before thrombectomy in stroke patients.
Analyzed data from ETIS and TETRIS registries
Compared outcomes between patients receiving tenecteplase and those undergoing thrombectomy only
Evaluated various clinical endpoints related to stroke recovery
Findings suggest potential benefits of adding tenecteplase to thrombectomy
Patients receiving both treatments reported better outcomes compared to thrombectomy alone
Further validation of these results is recommended in broader populations

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Observational research compares outcomes of IV tenecteplase with thrombectomy in stroke patients, indicating potential treatment benefits.

NCT03776877 (ETIS registry) and NCT05534360 (TETRIS registry).

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Gerschenfeld et al. (2026) studied this question.

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