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Transplantation of neuronal-induced human mesenchymal stem cells improves recovery from spinal cord injury, suggesting a therapeutic potential.
NI-hADSC transplantation improved functional recovery in SCI by modulating astrogliosis. The modulation of astrogliosis was likely to be achieved through selective suppression of detrimental A1 astrocytes, potentially via STAT3 signaling. However, the protective effect of NI-hADSCs on astrogliosis diminished during the subacute SCI period and was spatially restricted to the perilesional area.
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Lee et al. (2026) studied this question.
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