Association of cardiovascular-kidney-metabolic syndrome stages with MASLD prevalence and liver fibrosis severity: evidence from traditional and machine learning approaches

Q: What does this research mean for the field?

Higher stages of cardiovascular-kidney-metabolic syndrome (CKM) are significantly associated with increased prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) and advanced liver fibrosis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

Yijie Zheng; Ting Li; Shiqi Guo; Jinghai Song

doi:10.1186/s40001-026-04037-0

February 14, 2026European journal of medical researchOpen Access

Association of cardiovascular-kidney-metabolic syndrome stages with MASLD prevalence and liver fibrosis severity: evidence from traditional and machine learning approaches

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Key Points

To explore the relationship between CKM syndrome stages, MASLD prevalence, and liver fibrosis severity.
Used traditional and machine learning approaches for analysis.
Identified key metabolic domains like adiposity and lipid metabolism.
Evaluated associations between CKM stages and liver conditions.
CKM stages are linked to increased MASLD prevalence.
Advanced liver fibrosis and cirrhosis are associated with higher CKM stages.
Machine learning highlights three main contributors: adiposity, glycemic control, and lipid metabolism.

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Implication

Analysis associates CKM stages with MASLD prevalence and liver fibrosis severity, suggesting metabolic impacts.

Abstract

CKM stage was significantly associated with MASLD prevalence, advanced liver fibrosis, and cirrhosis. Machine learning interpretation highlighted adiposity, glycemic control, and lipid metabolism as the principal contributors, suggesting that these CKM-related metabolic domains may contribute to MASLD and fibrotic burden.

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Cite This Study

Zheng et al. (2026) studied this question.

synapsesocial.com/papers/699405254e9c9e835dfd5fc7 https://doi.org/10.1186/s40001-026-04037-0

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Association of cardiovascular-kidney-metabolic syndrome stages with MASLD prevalence and liver fibrosis severity: evidence from traditional and machine learning approaches

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Association of cardiovascular-kidney-metabolic syndrome stages with MASLD prevalence and liver fibrosis severity: evidence from traditional and machine learning approaches

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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