Association of cardiovascular-kidney-metabolic syndrome stages with MASLD prevalence and liver fibrosis severity: evidence from traditional and machine learning approaches

Key Points

• To explore the relationship between CKM syndrome stages, MASLD prevalence, and liver fibrosis severity.
• Used traditional and machine learning approaches for analysis.
• Identified key metabolic domains like adiposity and lipid metabolism.
• Evaluated associations between CKM stages and liver conditions.
• CKM stages are linked to increased MASLD prevalence.
• Advanced liver fibrosis and cirrhosis are associated with higher CKM stages.
• Machine learning highlights three main contributors: adiposity, glycemic control, and lipid metabolism.